Article ID Journal Published Year Pages File Type
4336325 Journal of Neuroscience Methods 2008 7 Pages PDF
Abstract

Synapses are individually operated, computational units for neural communication. To manipulate physically individual synapses in a living organism, we have developed a laser ablation technique for removing single synapses in live neurons in C. elegans that operates without apparent damage to the axon. As a complementary technique, we applied microfluidic immobilization of C. elegans to facilitate long-term fluorescence imaging and observation of neuronal development. With this technique, we directly demonstrated the existence of competition between developing synapses in the HSNL motor neuron.

Related Topics
Life Sciences Neuroscience Neuroscience (General)
Authors
, , , , , , ,