Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4336443 | Journal of Neuroscience Methods | 2007 | 10 Pages |
Abstract
Recordings of extracellular neural activity are used in many clinical applications and scientific studies. In most cases, these signals are analyzed as a point process, and a spike detection algorithm is required to estimate the times at which action potentials occurred. Recordings from high-density microelectrode arrays (MEAs) and low-impedance microelectrodes often have a low signal-to-noise ratio (SNRÂ <Â 10) and contain action potentials from more than one neuron. We describe a new detection algorithm based on template matching that only requires the user to specify the minimum and maximum firing rates of the neurons. The algorithm iteratively estimates the morphology of the most prominent action potentials. It is able to achieve a sensitivity of >90% with a false positive rate of <5Â Hz in recordings with an estimated SNRÂ =Â 3, and it performs better than an optimal threshold detector in recordings with an estimated SNRÂ >Â 2.5.
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Neuroscience
Neuroscience (General)
Authors
Sunghan Kim, James McNames,