Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4337050 | Journal of Neuroscience Methods | 2006 | 19 Pages |
Abstract
Brain surgery, and in particular epilepsy surgery, offers the unique opportunity to study viable human central nervous tissue in vitro. This does not only open a window to address the basic mechanisms underlying human disease, such as epilepsy, but it allows to venture into investigating neurophysiological functions per se. In the present paper, we describe the most commonly used methods in the electrophysiological (and, at least to some extent, also histochemical and molecular) analysis of human tissue in vitro. In addition, we consider the pitfalls and limitations of such studies, in particular regarding the issue of tissue sampling procedures and control experiments.
Keywords
Related Topics
Life Sciences
Neuroscience
Neuroscience (General)
Authors
Rüdiger Köhling, Massimo Avoli,