Neuromedin U receptor 2 knockdown in the paraventricular nucleus modifies behavioral responses to obesogenic high-fat food and leads to increased body weight

•Knock down of NMUR2 in the PVN stimulates intake of an obesogenic diet resulting in increased body weight.•NMUR2 signaling in the PVN regulates dietary preference.•NMUR2 knockdown in the PVN increases binge-type eating behavior.

Neuromedin U (NMU) is a highly conserved neuropeptide which regulates food intake and body weight. Transgenic mice lacking NMU are hyperphagic and obese, making NMU a novel target for understanding and treating obesity. Neuromed