| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 4337871 | Neuroscience | 2013 | 19 Pages |
Abstract
Striatal projection neurons undergo a massive loss of dendritic spines in Parkinson's disease, while they display an abnormal overgrowth of “thin and immature” spines after chronic cocaine exposure. Accumbens D1 dopamine receptor-containing neurons are preferentially affected in response to chronic cocaine exposure. Dopamine and glutamate are key regulators of this spine plasticity. Opposite calcium-mediated regulation of the myocyte enhancer factor 2 (MEF2) induces these structural changes.
Keywords
VGLUT2VTASubstantia nigra pars reticulataSTNcdk5MSNspKaSNRVGLUT1SNC6-HydroxydopamineNACPSDaccumbensCorticostriatalRCSRRAMEF2Postsynaptic densities6-OHDAcyclic AMPcAMPStriatumParkinson’s diseasethalamostriatalsubstantia nigrasubstantia nigra pars compactavesicular glutamate transporter 2vesicular glutamate transporter 1DopamineCAMcyclin-dependent kinase 5myocyte enhancer factor 2retrorubral areaCANventral tegmental areamedium spiny neuronsNucleus accumbensSubthalamic nucleusprotein kinase ACalmodulinCalcineurinCocaineglutamateGlobus pallidus
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Authors
R.M. Villalba, Y. Smith,