Long-term treatment with standardized extract of Ginkgo biloba L. enhances the conditioned suppression of licking in rats by the modulation of neuronal and glial cell function in the dorsal hippocampus and central amygdala

Article ID	Journal	Published Year	Pages	File Type
4338040	Neuroscience	2013	17 Pages	PDF

Abstract

âº Long-term treatment with Ginkgo biloba extract improves fear memory. âº This effect is related to an increase of CREB-1 and GFAP expression in the DH and AC. âº Present results suggest a role of the DH in the acquisition of lick suppression. âº The amygdala may have a role in the effects of EGb on the expression of conditioned fear. âº This effect is correlated with changes in the GAP-43 and CREB-1 expression.

Keywords

CREB CA1 ERK GAP-43 EGB extract of Ginkgo biloba BIS Cer Behavioral Inhibition System Amygdaloid complex conditioned stimulus dorsal hippocampus Conditioned emotional response cAMP-responsive element-binding protein cingulate cortex extracellular-signal-regulated kinase