Dysregulation of iron protein expression in the G93A model of amyotrophic lateral sclerosis

Article ID	Journal	Published Year	Pages	File Type
4338091	Neuroscience	2013	8 Pages	PDF

Abstract

âº Upregulation of iron genes and increased iron levels in G93A-SOD1 cells. âº Disturbed TfR1 modulation by iron in G93A-SOD1 cells. âº Upregulation of mitochondrial Fe import genes in G93A-SOD1 cells.

Keywords

FCS tris buffered saline with tween-20 MDA IscU dihydrodichlorofluorescein diacetate Fxn TfR1 iron proteins β2MG DMT1 TBST SOD1 dichlorodihydrofluorescein Dulbecco’s-modified Eagle’s medium DCFH-DA Deferoxamine PBS DMEM SDS DFO Dcf FAC HEPES Transferrin ROS β2-microglobulin Hydrogen peroxide cycle threshold Ferric Ammonium Citrate EDTA ethylene diamine tetraacetic acid amyotrophic lateral sclerosis hydroxyethyl piperazineethanesulfonic acid ALS Retinoic acid electron transport chain sodium dodecyl sulfate fetal calf serum superoxide dismutase 1 Frataxin malondialdehyde Divalent metal transporter 1 Phosphate-buffered saline wild type H2O2 ETc Reactive oxygen species transferrin receptor 1

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Life Sciences Neuroscience Neuroscience (General)

Dysregulation of iron protein expression in the G93A model of amyotrophic lateral sclerosis

Authors

M. Hadzhieva, E. Kirches, A. Wilisch-Neumann, D. Pachow, M. Wallesch, P. Schoenfeld, I. Paege, S. Vielhaber, S. Petri, G. Keilhoff, C. Mawrin,