| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 4338132 | Neuroscience | 2013 | 24 Pages |
Abstract
⺠Our aim was to gain insight into the mechanism of hyperphagia of BDNF KO mice. ⺠Feeding behavior and vagal afferent innervation of BDNF KO mice were characterized. ⺠Meal size and number were increased, suggesting deficits in satiation and satiety. ⺠Increased vagal motor activation by a meal suggested accommodation reflex was augmented. ⺠Augmented accommodation reflex may contribute to reduced satiation and satiety.
Keywords
IMIIntraganglionic laminar endingMeal microstructuremNTSSatiationVMHDMVDVCNTSHSDRT-PCRSAMPBSEGTALESBDNFVagal afferentsethylene glycol tetraacetic acidLower esophageal sphincterMeal patternImaImmunohistochemistryIHCanalysis of varianceANOVASatietyGastrointestinalarea postremaIntermeal intervalBrain-derived neurotrophic factordorsal vagal complexPhosphate-buffered salineknockoutnucleus of the solitary tractDorsal motor nucleus of the vagus nerveVentromedial hypothalamusreverse transcription polymerase chain reactionparaformaldehydeovernight
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Authors
E.A. Fox, J.E. Biddinger, K.R. Jones, J. McAdams, A. Worman,