Reversal of inhibition of putative dopaminergic neurons of the ventral tegmental area: Interaction of GABAB and D2 receptors

Article ID	Journal	Published Year	Pages	File Type
4338144	Neuroscience	2012	11 Pages	PDF

Abstract

âº Desensitization of GABAB receptors and dopamine D2 receptors was studied in the VTA. âº GABAB agonist baclofen produced long-lasting desensitization of GABAB receptors. âº Baclofen also produced desensitization of dopamine D2 receptors. âº D2 receptor desensitization also desensitized GABAB receptors. âº Reciprocal desensitization of GABAB & D2 receptors may play a role in therapeutics.

Keywords

aCSF GPCRs CGP35348 GRK DAergic G-protein coupled receptor kinase Gö6976 DIr G-protein coupled receptors long term potentiation LTP Dopamine Dopaminergic artificial cerebrospinal fluid muscimol