| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 4338188 | Neuroscience | 2012 | 12 Pages |
Abstract
⺠Chronic rapamycin decreased mTORC1 but not mTORC2 activity in mouse brains. ⺠Chronic rapamycin enhanced learning and memory in young adult C57BL/6J mice. ⺠Chronic rapamycin improved memory in aged mice. ⺠Chronic rapamycin decreased anxiety and depressive-like behavior at all ages. ⺠Monoamines were increased by rapamycin in midbrain but not in hippocampus.
Keywords
PKB5-HTTBS-T5-HIAATORDOPACmTORVTAEPI5-hydroxytryptaminenorepinephrine transporter3,4-dihydroxyphenylacetic acid5-hydroxyindolacetic acidAnxietyDepressionlong-term depressionEpinephrineAlzheimer’s diseasePars compactaMemoryNETDopamineLTDMonoaminesventral tegmental areanorepinephrinetarget of rapamycinmammalian target of rapamycinraphe nucleihomovanillic acidprotein kinase BBrain agingHVAhigh performance liquid chromatographyHPLC
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Authors
J. Halloran, S.A. Hussong, R. Burbank, N. Podlutskaya, K.E. Fischer, L.B. Sloane, S.N. Austad, R. Strong, A. Richardson, M.J. Hart, V. Galvan,