| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 4338192 | Neuroscience | 2012 | 13 Pages |
Abstract
⺠The cellular effects of mAChR activation were examined in human neocortical slices. ⺠Intracellular recordings revealed: CCh increases AP firing via M1 mAChR/KV7 channels. ⺠CCh decreases GABA release via activation of M2 mAChR. ⺠CCh attenuates glutamate release via activation of M4 mAChR. ⺠These effects are discussed towards hyperexcitability and cognition in human cortex.
Keywords
EGTABFNCmAChRM-currentIPSPTLECCHDMSOEPSPethylene glycol tetraacetic acidBenign Familial Neonatal ConvulsionsGamma aminobutyric acidCNSDimethylsulfoxidecentral nervous systemHuman epilepsytemporal lobe epilepsyMembrane potentialexcitatory postsynaptic potentialinhibitory postsynaptic potentialCarbacholGABAmuscarinic acetylcholine receptorMuscarinic acetylcholine receptors
Related Topics
Life Sciences
Neuroscience
Neuroscience (General)
Authors
S. Gigout, S. Wierschke, T.-N. Lehmann, P. Horn, C. Dehnicke, R.A. Deisz,