| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 4338217 | Neuroscience | 2012 | 13 Pages |
Abstract
⺠Tat-PTD increased the penetrability of haFGF to reach the brains via intranasal administration. ⺠TAT-haFGF improved learning and memory abilities and attenuated disease progression of SAMP8 AD mice. ⺠The mechanism is related to regulation of neurotransmitters, Aβ pathology and oxidative stress.
Keywords
SAMR1PBSMDATat-PTDMWMSAMP8NGFBCANOSAβ1–42GSH-PxAChAChEIntranasal administrationAcetylcholineAcetylcholinesterasebicinchoninic acidAlzheimer’s diseaseTATELISAEnzyme-linked immunosorbent assayMorris water maze testSODBBBBlood–brain barrierSuperoxide dismutasenerve growth factormalondialdehydePhosphate-buffered salineNitric oxidenitric oxide synthaseChATcholine acetyltransferaseGlutathione
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Authors
G. Lou, Q. Zhang, F. Xiao, Q. Xiang, Z. Su, L. Zhang, P. Yang, Y. Yang, Q. Zheng, Y. Huang,