Chronic restraint stress decreases glial fibrillary acidic protein and glutamate transporter in the periaqueductal gray matter

Article ID	Journal	Published Year	Pages	File Type
4338226	Neuroscience	2012	10 Pages	PDF

Abstract

âº Chronic stress caused mechanical hypersensitivity and aggressive behavior. âº Chronic stress induced decrease of GFAP and EAAT2 levels in the PAG. âº These findings suggest a dysfunction of the PAG after chronic stress.

Keywords

ventrolateral PAG PLSD lPAG SIH vlPAG RVM TTBS EAAT PAG PWT PPARγ SDS GFAP TBS BSA Tris-buffered saline containing 0.1% Tween-20 paw withdrawal threshold bovine serum albumin Restraint stress Sprague–Dawley Immunoreactivity phosphate buffer Tris-buffered saline protected least significant difference Glutamate transporter excitatory amino acid transporter CNS Room temperature rostral ventromedial medulla sodium dodecyl sulfate central nervous system descending system Periaqueductal gray matter Stress-induced hyperalgesia Hyperalgesia Glial fibrillary acidic protein Peroxisome proliferator-activated receptor gamma