Dicer is required for proliferation, viability, migration and differentiation in corticoneurogenesis

Article ID	Journal	Published Year	Pages	File Type
4338229	Neuroscience	2012	11 Pages	PDF

Abstract

âº Dicer loss causes mis-localized progenitor cells and disorganized cortical lamina. âº Dicer ablation reduces cell cycle kinetics in the developing cortex. âº Without Dicer there is early cell death in the developing cerebral cortex. âº Dicer loss causes dysregulated differentiation and migration markers. âº Dicer depletion causes a precocious induction of astrocyte differentiation.

Keywords

PFA PH3 NPC Dcx SVZ IdU ISH 5′-bromo-2′-deoxyuridine In situ hybridization Immunohistochemistry IHC BrdU doublecortin Dicer neural progenitor cell cortical plate Post-transcriptional regulation ventricular zone marginal zone subventricular zone MicroRNA paraformaldehyde Corticogenesis