Morphological and genetic activation of microglia after diffuse traumatic brain injury in the rat

Article ID	Journal	Published Year	Pages	File Type
4338249	Neuroscience	2012	11 Pages	PDF

Abstract

âº Morphologically activated microglia seen up to 28Â days after diffuse brain injury. âº Inflammatory genes acutely elevated in thalamus & cortex after diffuse TBI. âº Anti-inflammatory genes acutely elevated after diffuse TBI. âº Translocator protein 18Â kDa receptor binding validated qPCR results. âº Acute ibuprofen administration attenuated classical inflammatory genes in the VPM.

Keywords

TBI S1BF TSPO qRT-PCR VPM Gap43 Iba-1 FPI Traumatic brain injury Fluid percussion injury Anti-inflammatory Classical activation MHC major histocompatibility complex ionized calcium binding adaptor molecule 1 Neuroplasticity ventral posterior medial nucleus quantitative real-time PCR growth-associated protein 43