| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 4338254 | Neuroscience | 2012 | 14 Pages |
Abstract
⺠Uterine tissue implanted in gastrocnemius muscle produced endometriosis-like lesions. ⺠Lesions exhibited mechanical hyperalgesia and increased nociceptor firing in vivo. ⺠Muscular invasion by endometrial cells and markers for nociceptors was observed. ⺠Progesterone and leuprolide inhibited of mechanical hyperalgesia in cystic lesions. ⺠This novel approach provides insight into our understanding of endometriosis pain.
Keywords
DRGTriton XGnRHIB4Gap43CGRPDAPIPBSNGSEGTAHEPESFITCdorsal root ganglion4′,6-diamidino-2-phenylindole4-(2-hydroxyethyl)-1-piperazineethanesulfonic acidDiIethylene glycol tetraacetic acidEndometriosisNociceptorsisolectin B4chronic paingrowth associated protein 43normal goat serumfluorescein isothiocyanateLeuprolidePhosphate-buffered salineGonadotropin-releasing hormoneMechanical hyperalgesiaProgesteronecalcitonin gene-related peptide
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Authors
P. Alvarez, X. Chen, J. Hendrich, J.C. Irwin, P.G. Green, L.C. Giudice, J.D. Levine,