| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 4338256 | Neuroscience | 2012 | 13 Pages |
Abstract
⺠mRNA expression patterns were examined in male and female rat hippocampi at postnatal days 5 and 8. ⺠The effects of chronic neonatal nicotine exposure on mRNA expression were compared in males and females. ⺠Males have higher expression of NKCC1, BDNF and NR2A and lower expression of NR2B at postnatal day 5. ⺠Postnatal nicotine exposure increases KCC2 and BDNF expression in male but not female hippocampus. ⺠No sex or treatment effect on mRNA expression was observed at postnatal day 8.
Keywords
NR2ANR2BNMDA receptor subunit 2BRODnAChRNMDA receptor subunit 2ANKCC1NMDAGABAergicKCC2NMDARBDNFIn situ hybridizationNMDA receptorEDTAEthylenediaminetetraacetic acidphosphate bufferrelative optical densityDevelopmentpostnatal dayCNNdentate gyrusBrain-derived neurotrophic factorNicotinicnicotinic acetylcholine receptor
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Authors
J.C. Damborsky, U.H. Winzer-Serhan,