Secondary mechanical allodynia and hyperalgesia depend on descending facilitation mediated by spinal 5-HT4, 5-HT6 and 5-HT7 receptors

Article ID	Journal	Published Year	Pages	File Type
4338294	Neuroscience	2012	13 Pages	PDF

Abstract

âº Formalin increased the 5-HT in the ipsilateral dorsal part of the spinal cord. âº I.t. 5,7-DHT reduced spinal 5-HT and prevented secondary allodynia/ hyperalgesia. âº I.t. 5-HT4/6/7 agonists increased secondary mechanical allodynia/hyperalgesia. âº I.t. 5-HT4/6/7 antagonists prevented secondary mechanical allodynia/hyperalgesia. âº I.t. 5-HT4/6/7 antagonists reversed secondary mechanical allodynia/hyperalgesia.

Keywords

DRG SB-269970 RVM 5-HT Tph-2 pKa CGRP dorsal root ganglion 5,7-DHT cyclic AMP RNAi Cyclic adenosine monophosphate Secondary allodynia i.t.γ-aminobutyric acid intrathecal tryptophan hydroxylase-2 chronic pain ipsilateral rostral ventromedial medulla Formalin secondary hyperalgesia protein kinase A calcitonin gene-related peptide contralateral GABA 5-HT receptors