| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 4338372 | Neuroscience | 2012 | 11 Pages |
Abstract
â¶SMI attenuates beta amyloid-induced neurodegenerative changes in cultured neurons. â¶BDNF protein levels were decreased by Aβ25-35 and elevated by SMI. â¶Trk B inhibitor K252a or neutralizing anti-BDNF antibody abolished the action of SMI. â¶In SH-SY5Y cells, SMI elevated the BDNF transcription rate but did not affect its degradation. â¶qRT-PCR showed that SMI mainly elevated IV and VI transcripts of BDNF mRNA.
Related Topics
Life Sciences
Neuroscience
Neuroscience (General)
Authors
R. Zhang, Z. Wang, P.A. Howson, Z. Xia, S. Zhou, E. Wu, Z. Xia, Y. Hu,