Distribution of CB1 cannabinoid receptors and their relationship with mu-opioid receptors in the rat periaqueductal gray

Article ID	Journal	Published Year	Pages	File Type
4338466	Neuroscience	2012	10 Pages	PDF

Abstract

âº CB1 receptor expression is diffuse and extensive in the periaqueductal gray (PAG). âº The mu-opioid peptide (MOP) and CB1 receptors co-localize in many PAG neurons. âº CB1 labeling was mostly somatodendritic, but CB1 axon terminals were also detected. âº The pattern and extent of CB1 labeling was similar in the dlPAG and vlPAG. âº Chronic morphine or THC administration had no effect on CB1 receptor density.

Keywords

CB1 cannabinoid 1 NIDA MOP PAG EMS ERK THC ROI cyclic AMP BSA cAMP DMSO MAPK bovine serum albumin immunoreactive phosphate buffer Tris-buffered saline descending modulation periaqueductal gray Pain Dimethyl sulfoxide Antinociception national institute on drug abuse region of interest -ir mitogen-activated protein kinase