Upregulation of high-affinity GABAA receptors in cultured rat dorsal root ganglion neurons

Article ID	Journal	Published Year	Pages	File Type
4338482	Neuroscience	2012	10 Pages	PDF

Abstract

â¶GABAA currents in DRG neurons change with time in culture. â¶High-affinity “extrasynaptic” GABAA currents are increased. â¶Î´-subunit-containing receptors already present are trafficked to the membrane. â¶An increase in Ï-subunit expression and functional receptors is also detected.

Keywords

SDS DRG HEPES sqRT-PCR TACA 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid THIP minimal essential media sodium dodecyl sulfate Primary afferent Protein trafficking MEM Nociceptor Presynaptic inhibition ligand-gated ion channel dorsal root ganglia