| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 4338483 | Neuroscience | 2012 | 7 Pages |
Abstract
â¶Retinoic acid and cytokines change the precursor cell secretome toward an astroglial pattern. â¶Retinoic acid activates the JNK phosphorylation pathway. â¶Cytokines inhibit retinoic acid-induced JNK activation in a PI3K-dependent manner. â¶Inhibition of PI3K potentiates JNK activation by retinoic acid. â¶JNK could mediate a negative feedback loop for PI3K-driven GFAP expression.
Keywords
JnkGFAPmTORBMP-2PI3KERKTGF-βLIFDNA-PKcsPAK1PDK1c-Jun N-terminal kinaseMAPKRetinoic acidNeural precursor cellstumor growth factor-βleukemia inhibitory factorphosphatidylinositol-3-kinasemammalian target of rapamycinPhosphoinositide-dependent kinase-1Glial fibrillary acidic proteinBone morphogenetic protein-2mitogen-activated protein kinase
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Authors
F. Herrera, P. Maher, D. Schubert,