Spinal matrix metalloproteinase 3 mediates inflammatory hyperalgesia via a tumor necrosis factor-dependent mechanism

Article ID	Journal	Published Year	Pages	File Type
4338643	Neuroscience	2012	12 Pages	PDF

Abstract

â¶IT MMP antagonism attenuates peripheral inflammation-induced pain-like behavior. â¶IT MMP-3 induces pain-like behavior. â¶Spinal MMP-3 action requires TNF activity.

Keywords

TNF-alpha converting enzyme LPS APMA SDS FBS TNF Mmps GM6001 PBS MMP-3 TACE DMSO P/S p-aminophenylmercuric acetate Allodynia inflammation intrathecal interleukin Pain Dimethyl sulfoxide TIMP sodium dodecyl sulfate fetal bovine serum tumor necrosis factor Phosphate buffered saline lipopolysaccharide Matrix metalloproteinase 3 Matrix metalloproteinases Tissue inhibitor of metalloproteinase Hyperalgesia Penicillin/streptomycin