Intrinsic dynamics and synaptic inputs control the activity patterns of subthalamic nucleus neurons in health and in Parkinson's disease

▶Subthalamic neurons are autonomously active cells. ▶Spontaneous activity in STN neurons depends on persistent sodium current. ▶The autonomous activity of the STN cells shapes their responses to inputs. ▶The dopaminergic innervation controls STN intrinsic and synaptic properties.