Potent suppression of stretch reflex activity after systemic or spinal delivery of tizanidine in rats with spinal ischemia-induced chronic spastic paraplegia

▶Tizanidine (α2-adrenoceptor agonist) is used clinically as a potent antispasticity drug. ▶Tizanidine treatment has comparable antispasticity effect in rat model of spasticity. ▶Tizanidine antispasticity effect is mediated by α2A adreno- and I receptor.