| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 4338810 | Neuroscience | 2011 | 13 Pages |
Abstract
â¶Neonatal LPS exposure results in oligodendrocyte and white matter injury. â¶rhIGF-1 administered through intranasal infusion can penetrate into the neonatal rat brain. â¶Intranasal infusion of IGF-1 up to 2 h after LPS exposure attenuates LPS-induced brain injury. â¶Intranasal infusion of IGF-1 improved neurobehavioral deficits induced by LPS in juvenile rats. â¶rhIGF-1 attenuates LPS-induced apoptotic cell death, but not LPS-induced acute immune responses.
Keywords
TNFαPMNLPSMBPPI3KPFAIGF-1IL-1βIntranasal administrationOligodendrocyteinsulin-like growth factor-1Interleukin-1 betatumor necrosis factor alphaTUNELpostnatal day 5blood brain barrierBBBInflammatory cytokinePeriventricular leukomalaciaApoptotic cell deathPVLparaformaldehydeMyelin basic proteinPolymorphonuclearolfactory bulb
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Authors
Z. Cai, L.-W. Fan, S. Lin, Y. Pang, P.G. Rhodes,