Minocycline promotes remyelination in aggregating rat brain cell cultures after interferon-Î³ plus lipopolysaccharide-induced demyelination

Article ID	Journal	Published Year	Pages	File Type
4338838	Neuroscience	2011	9 Pages	PDF

Abstract

â¶Minocycline attenuated the inflammatory response triggered by IFN-Î³ plus LPS. â¶Minocycline did not prevent the IFN-Î³ plus LPS-induced demyelination. â¶Minocycline promoted remyelination by enhanced maturation of OPC.

Keywords

PBS LPS MOG MBP IB4 IFN-γ OPCs Neuroinflammation interferon-γ DIV day in vitro Oligodendrocyte precursor cells Phosphate buffered saline lipopolysaccharide Microglia map mitogen-activated protein Myelin basic protein myelin oligodendrocyte glycoprotein