Neuroprotection of Scutellarin is mediated by inhibition of microglial inflammatory activation

Article ID	Journal	Published Year	Pages	File Type
4338900	Neuroscience	2011	11 Pages	PDF

Abstract

â¶Scutellarin inhibits LPS-induced microglial activation. â¶Scutellarin inhibits IFN-Î³-induced microglial activation. â¶Scutellarin provides neuroprotection through inhibition of microglia activation.

Keywords

NF-κB STAT1α Scutellarin IFN-γ IL-1β iNOS ERK FBS Jnk DMEM LPS c-Jun N-terminal kinase MAPK Dulbecco's modified Eagle's medium ROS inflammation interferon-γ Interleukin-1β tumor necrosis factor-α conditioned media fetal bovine serum inducible nitric oxide synthase extracellular signal regulated kinase TNF-α nuclear factor κB lipopolysaccharide Neuroprotection Microglia Nitric oxide mitogen-activated protein kinase Reactive oxygen species