Hypoxia-induced hypothermia mediated by noradrenaline and nitric oxide in the rostromedial preoptic area

Article ID	Journal	Published Year	Pages	File Type
4339123	Neuroscience	2011	9 Pages	PDF

Abstract

â¶Carotid chemoreceptors mediate hypothermia elicited by acute hypoxia. â¶Hypoxia activates noradrenergic afferents in the rostromedial preoptic area (POA). â¶Activation of Î±1-adrenoceptors induces nitric oxide synthase in the rostromedial POA. â¶Preoptic nitric oxide activates efferent mechanisms for heat-loss responses.

Keywords

VCO2 NG-monomethyl-d-arginine POA d-NMMA NOS Anapyrexia BAT NG-monomethyl-L-arginine Carotid chemoreceptor MNPO OVLT L-NMMA α1-Adrenoceptor organum vasculosum of the lamina terminalis brown adipose tissue Thermoregulation colonic temperature Coefficient of Variation Preoptic area noradrenaline sodium nitroprusside Nitric oxide nitric oxide synthase median preoptic nucleus Hypothalamus SNP