Subtype-specific reduction of voltage-gated calcium current in medium-sized dorsal root ganglion neurons after painful peripheral nerve injury

▶We examine neuronal Ca2+ current loss that follows painful peripheral nerve injury. ▶Ca2+ current in DRG neurons decreases for both L- and N-channel subtypes. ▶This effect is evident during both square and AP waveform depolarizations. ▶The activation curve shifts right for N-type current after injury. ▶Injury does not affect N-type channel number or unitary current.