Environmental living conditions introduced during forced abstinence alter cocaine-seeking behavior and Fos protein expression

Article ID	Journal	Published Year	Pages	File Type
4339193	Neuroscience	2010	10 Pages	PDF

Abstract

â¶Environmental enrichment housing during forced abstinence reduces cue-elicited cocaine-seeking behavior relative to both isolated and social-housed controls. â¶Environmental enrichment attenuates cue-elicited Fos protein expression throughout mesocorticolimbic and nigrostriatal circuitry. â¶Social housing alone reduces cue-elicited cocaine-seeking behavior relative to isolated controls. â¶Social housing alone attenuates cue-elicited Fos protein expression within nigrostriatal circuitry.

Keywords

VTA substantia nigra pars reticulate isolated condition BNST PRL OFC NAcc CREB SNR CRF NAC PBS CPP PFC NACs NGS BLA SNC basolateral amygdala CeA Central amygdala Incentive motivation conditioned place preference substantia nigra pars compacta normal goat serum Neurocircuitry dentate gyrus corticotropin releasing factor Environmental enrichment infralimbic cortex prefrontal cortex Somatosensory cortex prelimbic cortex Phosphate-buffered saline Ventral subiculum craving ventral tegmental area fixed ratio Variable ratio Nucleus accumbens nucleus accumbens core nucleus accumbens shell bed nucleus of the stria terminalis cAMP response element binding protein immediate early gene