| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 4339233 | Neuroscience | 2011 | 10 Pages |
Abstract
â¶Morphine (MOR)-induced respiratory depression (RD) was not observed in nerve-ligated mice. â¶This attenuation was reversed by 5-HT4a receptor antagonist. â¶5-HT4 receptor agonist, mosapride, antagonized the MOR-induced RD. â¶Expression of 5-HT4a receptor in brainstem was enhanced in nerve-ligated mice. â¶5-HT4a receptor up-regulation under chronic pain causes decrease in MOR-induced RD.
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Authors
J. Kamei, M. Ohsawa, S.-S. Hayashi, Y. Nakanishi,