Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4340872 | Neuroscience | 2008 | 9 Pages |
Abstract
In cultured rat cortical neurons THs prevented glutamate-induced neuronal death at concentrations similar to those effective on glutamatergic receptors. Taken together our data show for the first time that THs can rapidly affect ionotropic glutamatergic receptors in hippocampal neurons, an effect that could have an important role in their modulation of brain function in physiological and pathological states.
Keywords
DMEphorbol 12-myristate 13-acetateIC50BMEmEPSCN-methyl-d-aspartateNMDATTX3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromidePMAMTTkainic acidtetrodotoxinlong-term potentiationLTPthyroxineminiature excitatory post-synaptic currentDIVdays in vitropostnatal dayneurobasal mediumAccess resistanceThyroid hormonePatch-clampNMDA receptorsThyroid receptorAMPA receptors
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Authors
G. Losi, G. Garzon, G. Puia,