| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 4340884 | Neuroscience | 2008 | 10 Pages |
Abstract
We propose that acute epileptiform discharges induced by pilocarpine treatment in the in vitro isolated brain preparation are mediated by a dose-dependent, atropine-sensitive muscarinic effect promoted by an increase in BBB permeability. Pilocarpine accumulation secondary to BBB permeability changes may contribute to in vivo ictogenesis in the pilocarpine epilepsy model.
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Authors
L. Uva, L. Librizzi, N. Marchi, F. Noe, R. Bongiovanni, A. Vezzani, D. Janigro, M. de Curtis,