Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4341048 | Neuroscience | 2009 | 21 Pages |
Abstract
Neuronal activity controls the strength of excitatory synapses by mechanisms that include changes in the postsynaptic responses mediated by AMPA receptors. These receptors account for most fast responses at excitatory synapses of the CNS, and their activity is regulated by various signaling pathways which control the electrophysiological properties of AMPA receptors and their interaction with numerous intracellular regulatory proteins. AMPA receptor phosphorylation/dephosphorylation and interaction with other proteins control their recycling and localization to defined postsynaptic sites, thereby regulating the strength of the synapse. This review focuses on recent advances in the understanding of the molecular mechanisms of regulation of AMPA receptors, and the implications in synaptic plasticity.
Keywords
NMDARpKasoluble N-ethylmaleimide-sensitive factor attachment protein receptorsTARPcGKIINMDAN-methyl-d-aspartateNP1NARPSNAREPKCLBDPI3-KmEPSCmGluRsABPPDZNCAMNPRPICK1SEPGluRδ2CaMKIIAMPARPSAPSDGFPAβFRAPTNFαERK6-Cyano-7-nitroquinoxaline-2,3-dioneBDNFmembrane-associated guanylate kinaseMAPKMAGUKPolysialic acidlong-term depressionBARBeta-amyloidSERpostsynaptic densitylong-term potentiationLTPtumor necrosis factor-αminiature excitatory postsynaptic currentligand-binding domainCAMSerineCNQXendoplasmic reticulumBrain-derived neurotrophic factortransmembranePhosphatidylinositol 3-kinasereceptor phosphorylationactivity-regulated cytoskeleton-associated proteinfluorescence recovery after photobleachingReceptor traffickingArcLTDCell adhesion moleculeneural cell adhesion moleculeglutamate receptor interacting proteingreen-fluorescent proteinprotein kinase AProtein kinase Cmitogen-activated protein kinaseNeuronal pentraxin 1extracellular signal-regulated kinaseGRIPglutamateAMPA receptorN-methyl-d-aspartate receptorMetabotropic glutamate receptors
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Authors
S.D. Santos, A.L. Carvalho, M.V. Caldeira, C.B. Duarte,