The role of cholinergic basal forebrain neurons in adenosine-mediated homeostatic control of sleep: Lessons from 192 IgG-saporin lesions

Article ID	Journal	Published Year	Pages	File Type
4341162	Neuroscience	2008	16 Pages	PDF

Abstract

Taken together, these results strongly suggest that cholinergic neurons in the BF are important for the SD-induced increase in adenosine as well as for its sleep-inducing effects and play a major, although not exclusive, role in sleep homeostasis.

Keywords

MCPO NF-κB NBTI PBS IgG VDB ChAT-ir GAD nucleus basalis magnocellularis RM-ANOVA REM aCSF NREM NBM HDB glutamic acid decarboxylase AChE Stereology Acetylcholinesterase Electroencephalogram EMG electromyogram repeated measures analysis of variance Immunotoxin immunoglobulin G phosphate buffer analysis of variance ANOVA rapid-eye movement medial septum Cholinergic lesion nuclear factor-κB Delta activity substantia innominata artificial cerebrospinal fluid Sleep deprivation Rat EEG magnocellular preoptic nucleus basal forebrain ChAT choline acetyltransferase