In vivo preconditioning with normobaric hyperoxia induces ischemic tolerance partly by triggering tumor necrosis factor-Î± converting enzyme/tumor necrosis factor-Î±/nuclear factor-ÎºB

Article ID	Journal	Published Year	Pages	File Type
4341984	Neuroscience	2008	8 Pages	PDF

Abstract

Although further studies are needed to clarify the mechanisms of brain ischemic tolerance, InHO and PrHO may partly exert their effects via triggering TACE/TNF-Î±/NF-ÎºB.

Keywords

IPC INRA tumor necrosis factor-α converting enzyme TACE Brain ischemic tolerance Normobaric hyperoxia TNF-a MCAO NDS IκB NF-κB ischemic preconditioning ROS middle cerebral artery occlusion Evans Blue BIT Ischemic tolerance tumor necrosis factor-α SOD Blood–brain barrier BBB Superoxide dismutase TNF-α nuclear factor-κB inhibitory κB neurologic deficit score room air Hyperoxia dry weight wet weight activator protein Reactive oxygen species