Article ID Journal Published Year Pages File Type
4342570 Neuroscience 2007 11 Pages PDF
Abstract
Rats selectively bred for low PPI showed some cognitive deficits that are apparent in a number of psychiatric disorders with deficient information processing. Specifically in both, spatial and operant behavioral paradigms, PPI low rats are deteriorated in their ability to modulate behavior based upon new changing information. They may thus provide a non-pharmacological model that can be used to evaluate new therapeutic strategies ranging from pharmacological treatment to functional neurosurgery.
Related Topics
Life Sciences Neuroscience Neuroscience (General)
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