Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4343529 | Neuroscience Letters | 2015 | 7 Pages |
Abstract
Sphingosine-1-phosphate (S1P) is a bioactive lipid which regulates proliferation, cell migration, survival and differentiation by specific receptors activation. We studied its effects on L-BMAA treated neuroblastoma cells (SH-SY5Y), an amino acid that can trigger neurodegenerative diseases such as amyotrophic lateral sclerosis/Parkinson dementia complex (ALS/PDC). We found that S1P protects from necrosis and prevents the GSK3 increasing as long as the PI3K/AKT pathway is active. Moreover, GSK3 inhibition protects against neuronal death caused by L-BMAA.
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Neuroscience
Neuroscience (General)
Authors
Emma Muñoz-Sáez, EstefanÃa de Munck GarcÃa, Rosa MarÃa Arahuetes Portero, Francisca Vicente, Francisco Javier Ortiz-López, Juan Cantizani, Begoña Gómez Miguel,