Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4343537 | Neuroscience Letters | 2015 | 5 Pages |
Abstract
Our previous investigations have revealed that cerebellar cholinergic innervation is involved in cardiovascular regulation. This study was performed to examine the effects of the muscarinic cholinergic receptor (mAChR) in the cerebellar cortex on blood pressure (BP) modulation in rats. Acetylcholine (ACh, 100Â mM), nonselective mAChR agonist (oxotremorineâM; Oxo-M, 10, 30 and 100Â mM) and 100Â mM ACh mixed with nonselective mAChR antagonist atropine (1, 3 and 10Â mM) were microinjected into the cerebellar cortex of anesthetized rats. Mean arterial pressure (MAP), maximal decreased MAP (MDMAP), and reaction time (duration required for BP to return to basal values) were measured and analyzed. The results showed that Oxo-M dose-dependently decreased MAP, increased MDMAP, and prolonged reaction time, which displayed a homodromous effect of ACh-mediated blood depressor response; meanwhile, atropine concentration-dependently blocked the effect of ACh on the BP regulation. In conclusion, the present study showed for the first time that mAChRs in cerebellar cortex could modulate somatic BP by participation in ACh-mediated depressor response.
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Authors
Peiling Zhou, Qingfeng Zhu, Ming Liu, Jing Li, Yong Wang, Changzheng Zhang, Tianmiao Hua,