Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4343706 | Neuroscience Letters | 2014 | 6 Pages |
Abstract
A total of 261subjects were included, of whom 36 had lacunar infarcts, 29 had severe WML, and 83 had CMB. In age-sex-adjusted models, narrower retinal arteriolar caliber, wider venular caliber and smaller arteriolar fractal dimension were associated with presence of multiple CMB. In contrast, no association was found with lacunar infarcts and WML volume. After multivariate adjustments, associations of venular caliber, arteriolar fractal dimensions and arteriolar tortuosity with CMB remained statistically significant. In conclusion, subjects with early structural changes in retinal microvasculature were more likely to have CMBs, supporting hypothesis that CMB may be an early manifestation of cerebral small vessel disease.
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Neuroscience
Neuroscience (General)
Authors
Saima Hilal, Yi-Ting Ong, Carol Y. Cheung, Chuen Seng Tan, Narayanaswamy Venketasubramanian, Wiro J. Niessen, Henri Vrooman, Ainur R. Anuar, Merwyn Chew, Christopher Chen, Tien Yin Wong, Mohammad Kamran Ikram,