| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 4343886 | Neuroscience Letters | 2013 | 9 Pages |
Abstract
- Ionotropic GABAA and glycine receptors in the dorsal horn regulate nociception.
- Ionotropic inhibition requires KCC2 activity to maintain low intracellular Clâ.
- A loss of inhibition via GABAA or glycine can cause hyperalgesia and allodynia.
- Increasing the activity of GABAA receptors or KCC2 restores normal nociception.
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Authors
Robert P. Bonin, Yves De Koninck,