| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 4344220 | Neuroscience Letters | 2012 | 4 Pages |
The present study was performed to explore the antinociceptive effects of M617, a selective galanin receptor 1 agonist, in the central nucleus of amygdala (CeA) of rats. Intra-CeA injection of 0.1 nmol, 0.5 nmol and 1 nmol of M617 induced dose-dependent increases in hindpaw withdrawal latencies (HWLs) to noxious thermal and mechanical stimulations in rats. Furthermore, rats received intra-CeA administration of M617 and galanin. The HWL to noxious thermal and mechanical stimulations increased markedly, and there were no significant differences in HWLs of rats received intra-CeA administration of M617 and galanin. The results demonstrated that intra-CeA injection of M617 induced significant antinociceptive effects in CeA of rats, indicating that galanin receptor 1 may be involved in M617-induced antinociception in the CeA of rats.
► Intra-central nucleus of amygdala injection of M617 induces antinociception. ► No significant differences between the M617- and galanin-induced antinociception. ► Galanin receptor 1 is involved in galanin-induced antinociception in the brain.
