| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 4344267 | Neuroscience Letters | 2012 | 4 Pages |
Abstract
⺠In an RBEC monolayer, LPS showed no effect on P-gp function. ⺠In the presence of microglia, LPS lowered P-gp function in RBECs. ⺠LPS-activated microglia induced P-gp dysfunction without altering its expression. ⺠An NADPH oxidase inhibitor reversed this effect of LPS-activated microglia. ⺠The decrease in P-gp activity in RBECs may be mediated by the NADPH oxidase pathway.
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Authors
Junichi Matsumoto, Shinya Dohgu, Fuyuko Takata, Tsuyoshi Nishioku, Noriko Sumi, Takashi Machida, Hiroyuki Takahashi, Atsushi Yamauchi, Yasufumi Kataoka,