| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 4344349 | Neuroscience Letters | 2012 | 9 Pages |
Abstract
⺠Angiogenesis is one of the major determinants of glioblastoma progression and maintenance. ⺠The process is maintained by a balance between pro- and anti-angiogenic factors. ⺠The action and function of several of these factors has been elucidated. ⺠While several of these factors are “druggable”, the ability to use gene therapy methodologies to alter the angiogenic milieu appears to be a logical avenue for translational research and possible clinical applications. ⺠In this review, we will highlight examples of pro- and anti-angiogenic targets, vectors utilized for delivery of target genes and challenges facing applications of gene therapy against glioma angiogenesis.
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Authors
NaTosha N. Gatson, E. Antonio Chiocca, Balveen Kaur,