Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4344401 | Neuroscience Letters | 2012 | 5 Pages |
Abstract
⺠HBHP is a heptamer peptide selected as a HMGB1 binding peptide using a phage display approach. ⺠HBHP was confirmed to bind A box region of HMGB1 in a pull-down assay. ⺠HBHP suppressed HMGB1-mediated neuronal cell death in primary cortical cultures. ⺠Intranasally delivered HBHP has a robust neuroprotective effect in the ischemic brain.
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Authors
Il-Doo Kim, Joo-Hyun Shin, Hye-Kyung Lee, Yin-Chuan Jin, Ja-Kyeong Lee,