Article ID Journal Published Year Pages File Type
4344401 Neuroscience Letters 2012 5 Pages PDF
Abstract
► HBHP is a heptamer peptide selected as a HMGB1 binding peptide using a phage display approach. ► HBHP was confirmed to bind A box region of HMGB1 in a pull-down assay. ► HBHP suppressed HMGB1-mediated neuronal cell death in primary cortical cultures. ► Intranasally delivered HBHP has a robust neuroprotective effect in the ischemic brain.
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Life Sciences Neuroscience Neuroscience (General)
Preview
Intranasal delivery of HMGB1-binding heptamer peptide confers a robust neuroprotection in the postischemic brain
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