Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4344561 | Neuroscience Letters | 2012 | 4 Pages |
The primate somatosensory system provides an excellent model system with which to investigate adult neural plasticity. Here, we report immunohistochemical staining data for the GluR1 and GluR2/3 AMPA receptor subunits in the cuneate nucleus of adult squirrel monkeys one week after median nerve compression. These data are compared to subunit changes in the area 3b cortex of the same animals. We report differences between control and deprived brainstem implying that deprivation induced changes in subunit expression mirror those reported in the cortex. There are significant increases in GluR1 receptor subunit staining intensity and significant decreases in GluR2/3 receptor subunit staining intensity. This pattern of expression resembles receptor configurations reported in developing sensory systems. Taken together, these results suggest that the brainstem and the cortex initially progress through a phase of developmental recapitulation prior to the onset of NMDA mediated adult somatosensory reorganization.
► GluR1 subunits are significantly increased suggesting increased Homomeric AMPAR. ► GluR2/3 subunits are significantly decreased suggesting lower GluR2/3 AMPAR. ► This pattern of subunit expression was also found in the somatosensory cortex.