| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 4344572 | Neuroscience Letters | 2012 | 6 Pages |
Abstract
⺠Oxidative stress can deteriorate survival of stem cells in cell replacement therapy. ⺠dl-3-n-butylphthalide (NBP) enhances rBMSCs' resistance to oxidative stress. ⺠NBP protects rBMSCs from oxidative stress through PI3K-Akt pathway. ⺠NBP could be a strategy to increase cell survival in cell replacement therapy.
Keywords
CrtMDAdl-3-n-ButylphthalideB cell lymphoma-2SFDANBPNT-3DCFH-DABcl-2FBSFCMPBSDMSOPI3K/AKTPI3K-AktROSHydrogen peroxideAntioxidantState Food and Drug AdministrationBaxanalysis of varianceANOVAOxidative stressCell replacement therapyDimethylsulfoxideSODfetal bovine serumBone marrow stem cellsSuperoxide dismutasephosphate buffer salinePhosphatidylserineFlow cytometrymalondialdehydeH2O2Bcl-2-associated X proteincaspaseReactive oxygen species
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Authors
Bo Sun, Meijiang Feng, Xiangyang Tian, Xiaowei Lu, Yunyun Zhang, Xianjin Ke, Susu Huang, Jingjing Cao, Xinsheng Ding,