| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 4344574 | Neuroscience Letters | 2012 | 6 Pages |
Molecular mechanisms regulating positions of oligodendrocyte precursor cells (OPCs) remain unclear in developing cerebral cortex. To explore the mechanisms, we investigated how Plexin-A4, receptor of Semaphorin in OPCs, is involved in the positioning. We found that Plexin-A4 knockout mice exhibited (1) an increased number of OPCs in both the upper- and middle-regions of the cortical plate, where both indirect- and direct-ligands of Plexin-A4, Sema3A and Sema6A, respectively, were continuously expressed, and (2) aberrant distributions of OPCs in both the intermediate zone and corpus callosum, where Plexin-A4 was richly expressed in wild-type mice. These results suggest that Plexin-A4 is involved in the precise positioning of OPCs in developing cerebral cortex.
► Distribution of OPCs was disturbed in the cortical plate in Plexin-A4 mutants. ► Both Sema3A and Sema6A were continuously expressed in the cortical plate. ► Number of OPCs was also decreased in the corpus callosum of the mutants.
