| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 4344626 | Neuroscience Letters | 2012 | 5 Pages |
Painful peripheral neuropathy induced by chronic ethanol consumption is a major medico-socioeconomical problem. The objective of present investigation was to study the effect of curcumin (20, 40 and 80 mg/kg; p.o.) in alcohol-induced neuropathy in rats. Ethanol (35% v/v, 10 g/kg; p.o.) was administered for 10 weeks which showed a significant decrease in thermal hyperalgesia, mechanical hyperalgesia, mechanical allodynia and nerve conduction velocity. It caused enhanced malondialdehyde, oxidative-nitrosative stress, total calcium levels, inflammatory mediators (TNF-α and IL-1β levels) along with DNA damage. Co-administration of curcumin and α-tocopherol for 10 weeks significantly and dose-dependently improved nerve functions, biochemical as well as molecular parameters and DNA damage in sciatic nerve of ethanol treated rats. Hence, it was concluded that curcumin is of potent therapeutic value in the amelioration of alcoholic neuropathy in rats and acts by inhibition of pro-inflammatory mediators like TNF-α and IL-1β.
Graphical abstractFigure optionsDownload full-size imageDownload high-quality image (129 K)Download as PowerPoint slideHighlights► Chronic alcohol administration (10 g/kg, b.i.d, p.o.) led to neuropathy in lab rats. ► Curcumin was administered at a dose of (20, 40, 80 mg/kg, p.o.) in neuropathic rats. ► Curcumin reduced oxidative stress, nitrite, calcium, TNF-α, IL-1β and DNA damage. ► Curcumin produced significant improvement in MNCV. ► Curcumin dose dependently ameliorates alcohol induced neuropathic pain.
